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KMID : 0369819800100030301
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Jorunal of Korean Pharmaceutical Sciences
1980 Volume.10 No. 3 p.301 ~ p.304
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Comparison of the Blood Concentration of Ampicillin and Lysinomethylene Ampicillin in Man
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김종갑/Kim JK
김영일/김봉희/Kim YI/Kim BH
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Abstract
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In order to increase the solubility and antibacterial activity of ampicillin, the lysinomethylene ampicillin trihydrate was synthesized. The blood concentrations of ampicillin trihydrate and synthetic lysinomethylene ampicillin trihydrate were determined in 10 healthy male volunteers by using large plate method with Sarcina lutea ATCC 9341. The mean blood concentration of synthetic lysinomethylene ampicillin trihydrate was higher ca. 1.3 times than that of ampicillin trihydrate in 10 test subjects after oral administration.
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